Drug-free pain relief

iovera°: press pause on knee pain — literally

iovera° uses precisely targeted cold to switch off the sensory nerves around your knee for months while they safely regenerate. No drugs, no surgery, no downtime — and when used before knee replacement, dramatically less need for opioids after.

  • Up to 6 months relief
  • No drugs
  • Office visit
  • Pre-surgery option
Clinician in black gloves preparing a patient's leg for an injection procedure.

iovera° Cryoneurolysis at a glance

Visit length
About 30–45 minutes
Anesthesia
Local numbing only
Relief window
Commonly up to 6 months
Downtime
Essentially none
Nerve damage
None — nerves regenerate fully

iovera° treats pain signaling, not the arthritis itself — it's a bridge to surgery, a surgical pain-control multiplier, or a quality-of-life tool, depending on your plan.

How freezing a nerve relieves pain

The sensory nerves around your knee — which carry pain but not movement signals — can be paused with cold. The iovera° handpiece delivers precise, targeted freezing through tiny probes, interrupting the nerve's ability to transmit pain. The nerve's structure isn't destroyed; it regenerates over months, fully functional. Until it does, the knee simply hurts less — commonly for up to six months. It's the same principle as ice on a sore joint, engineered to work at the nerve itself and last thousands of times longer.

Use one: before knee replacement, against opioids

This is where iovera° shines brightest in Dr. Morton's practice. Treating the knee's sensory nerves before knee replacement means you arrive at surgery with pain signaling already dialed down — and go through recovery needing meaningfully less medication of every kind. Combined with the opioid-sparing protocol (blocks, local anesthetic, scheduled non-opioids), it's a major reason patients report recovery hurt far less than they feared. Patients who fear opioids — or must avoid them — should ask about this specifically.

Infographic showing clinical trial results of iovera cryoneurolysis reducing knee pain for up to 90 days.
Manufacturer trial data: iovera° cryoneurolysis reduced knee pain for up to 90 days.

Use two: arthritis relief without surgery

For knee arthritis patients who aren't ready for replacement — or aren't candidates — iovera° offers months of relief without drugs, injections into the joint, or downtime. It pairs naturally with the rest of the arthritis ladder: quieter pain makes strengthening possible, and stronger muscles protect the joint. Relief is repeatable when nerves regenerate.

  • Knee arthritis pain limiting daily life or exercise
  • Patients avoiding or delaying surgery
  • Preparing for knee replacement with less-opioid recovery
  • Patients who can't tolerate NSAIDs or repeated cortisone

What the visit feels like

After mapping the target nerves, the skin is numbed and the handpiece applies focused cold treatment at several points around the knee — most patients describe pressure and brief cold sting. You walk out when it's done; normal activity resumes immediately, with possible numb patches and temporary soreness at treatment sites. Relief typically settles in over days. It's among the lowest-commitment treatments in orthopedics — and one of the most underused.

Medically reviewed by Paul N. Morton, MD, FAAOS, FAAHKS — board-certified orthopedic surgeon, fellowship-trained in adult hip & knee reconstruction and orthopedic trauma.

This page is for education only and isn’t a substitute for an exam and personalized advice — schedule a consultation to discuss your situation.

The difference

Why patients choose Dr. Morton

  • Drug-free relief lasting months, not hours
  • Slashes post-surgical opioid needs when used pre-operatively
  • Office procedure with essentially zero downtime
  • Repeatable — nerves regenerate fully
  • Part of a complete pain and arthritis strategy
  • Delivered by the surgeon who knows your whole plan

Frequently asked questions

Is iovera° permanent nerve damage?
No. The targeted freezing pauses nerve signaling without destroying the nerve's structure; nerves regenerate fully over months. That's why relief is temporary — and repeatable.
Will my knee be numb or weak afterward?
Small skin patches may feel numb temporarily, but the treated nerves are sensory only — the nerves controlling your muscles are untouched, so strength and movement are unaffected.
How is iovera° different from a cortisone shot?
Cortisone chemically calms inflammation inside the joint for weeks; iovera° physically pauses pain-nerve signaling for months without drugs. They work at different points in the pain pathway and are sometimes used together in one plan.
Does insurance cover iovera°?
Coverage varies — some plans cover it, particularly around knee replacement. The office verifies your benefits and quotes any out-of-pocket cost before treatment.
Can iovera° help me avoid knee replacement entirely?
It doesn't slow arthritis, but by controlling pain it can buy comfortable, active time — sometimes years when combined with strengthening and the rest of the ladder. When replacement eventually becomes right, you'll already know its best supporting act.

Ask whether iovera° belongs in your pain plan

Consultations in Honolulu, West Oahu, Hilo and Kona — most new patients are seen within one to two weeks — with telehealth when an in-person visit isn’t practical.

Paul Norio Morton, MD, FAAOS, FAAHKS · Hawai‘i’s first robotic hip & smart knee · Read patient reviews →

Most major plans accepted — we verify benefits before your visit. Traveling from off-island? See the fly-in patient program →

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